Doctors warn about side effects of sleeping pills and Tylenol. Tylenol is relatively safe when you take the recommended dose. Read the directions on the bottle You can take Tylenol for hangovers. Take acetaminophen with alcohol can also hurt liver. Doctors have known for many years that alcoholics (6+ drinks per day) should not take Tylenol and people who take the maximum dose of tylenol on a daily basis should not drink. Recovery is possible for anyone. The actual article says that overdosing on Tylenol is dangerous if you drink alcohol. Too much Tylenol can damage your liver and cause serious illness or death. Acetaminophen (Tylenol) Photo courtesy of Wikimedia Commons. A new study suggests that people who take the correct dose of acetaminophen, combined with a even a small amount of alcohol, have a 123 percent greater chance of getting kidney disease — yes, that's not a typo. Together they can cause diver damage or even death but it would have to be large doses or over a long period of time. In general, adults can take between 650 milligrams (mg) and 1,000 mg of acetaminophen every 4 to 6 hours. When this enzyme comes into contact with the acetaminophen, a toxic substance called NAPQI will be created, which can kill liver cells. Alcohol can cloud judgment and impair impulse control, making overdose more likely. Alcohol can do the same thing over time. According to one National Institutes of Health publication on alcohol and metabolism , liver damage effects may occur with as little of four to five "extra-strength" pills taken over the course of the day in people who consumed varying amounts of alcohol. The headline is misleading. Acetaminophen and Alcohol: Liver Damage. The amount of alcohol you drink (alcohol can increase the production of toxic NAPQI) If you take other medications with Tylenol. 2E1 enzyme is an enzyme that is produced in the liver as a result of sustained drinking over a few days. Acetaminophen, also known as paracetamol or Tylenol, is a drug that people use to treat mild-to-moderate pain and fever.. Both have an adverse effect on the liver. If you have alcohol on a chronic basis and take acetaminophen regularly, it can … Acetaminophen is probably the riskiest painkiller to take while drinking. Mixing alcohol and codeine, or any other combination of intoxicating substances, can lead to addiction and dependence. OTC pain medications: "One of the worst is acetaminophen," says Dr. MacKinnon. Some drugs, including opiods, dilantin, and others, may interact poorly with Tylenol and increase the risk of liver damage; certain herbal supplements can also interact with Tylenol and cause liver damage. 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